abstract：:Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...

journal_title：Genes

authors： Zimmer C,Riesch R,Jourdan J,Bierbach D,Arias-Rodriguez L,Plath M

更新日期：2018-05-02 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic diseases. It is caused by mutations in the NF1 gene encoding for the large protein, neurofibromin. Genetic testing of NF1 is cumbersome because 50% of cases are sporadic, and there are no mutation hot spots. In addition, the most recog...

journal_title：Genes

authors： Stella A,Lastella P,Loconte DC,Bukvic N,Varvara D,Patruno M,Bagnulo R,Lovaglio R,Bartolomeo N,Serio G,Resta N

更新日期：2018-04-17 00:00:00

abstract：:The Yangtze finless porpoise (Neophocaena asiaeorientalis ssp. asiaeorientalis) is a subspecies of the narrow-ridged finless porpoise (N. asiaeorientalis). In total, 714.28 gigabases (Gb) of raw reads were generated by whole-genome sequencing of the Yangtze finless porpoise, using an Illumina HiSeq 2000 platform. Afte...

journal_title：Genes

authors： Yuan Y,Zhang P,Wang K,Liu M,Li J,Zheng J,Wang D,Xu W,Lin M,Dong L,Zhu C,Qiu Q,Li S

更新日期：2018-04-16 00:00:00

abstract：:The nitrogen use efficiency (NUE) of crop plants is limited and enhancing it in rice, a major cereal crop, would be beneficial for farmers and the environment alike. Here we report the genome-wide transcriptome analysis of two rice genotypes, IR 64 (IR64) and Nagina 22 (N22) under optimal (+N) and chronic starvation (...

journal_title：Genes

authors： Sinha SK,Sevanthi V AM,Chaudhary S,Tyagi P,Venkadesan S,Rani M,Mandal PK

更新日期：2018-04-11 00:00:00

abstract：:Exposure to Formaldehyde (FA) results in many pathophysiological symptoms, however the underlying mechanisms are not well understood. Given the complicated modulatory role of intestinal microbiota on human health, we hypothesized that interactions between FA and the gut microbiome may account for FA's toxicity. Balb/c...

journal_title：Genes

authors： Guo J,Zhao Y,Jiang X,Li R,Xie H,Ge L,Xie B,Yang X,Zhang L

更新日期：2018-04-03 00:00:00

abstract：:Architectural proteins play key roles in genome construction and regulate the expression of many genes, albeit the modulation of genome plasticity by these proteins is largely unknown. A critical screening of the architectural proteins in five crop species, viz., Oryza sativa, Zea mays, Sorghum bicolor, Cicer arietinu...

journal_title：Genes

authors： Verma JK,Wardhan V,Singh D,Chakraborty S,Chakraborty N

更新日期：2018-03-28 00:00:00

abstract：:Listeria monocytogenes is a major human foodborne pathogen that is prevalent in the natural environment and has a high case fatality rate. Whole genome sequencing (WGS) analysis has emerged as a valuable methodology for the classification of L. monocytogenes isolates and the identification of virulence islands that ma...

journal_title：Genes

authors： Hilliard A,Leong D,O'Callaghan A,Culligan EP,Morgan CA,DeLappe N,Hill C,Jordan K,Cormican M,Gahan CGM

更新日期：2018-03-20 00:00:00

abstract：:Cytokinin oxidase/dehydrogenases (CKXs) play a critical role in the irreversible degradation of cytokinins, thereby regulating plant growth and development. Brassica napus is one of the most widely cultivated oilseed crops worldwide. With the completion of whole-genome sequencing of B. napus, genome-wide identificatio...

journal_title：Genes

authors： Liu P,Zhang C,Ma JQ,Zhang LY,Yang B,Tang XY,Huang L,Zhou XT,Lu K,Li JN

更新日期：2018-03-16 00:00:00

abstract：:Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This revi...

journal_title：Genes

authors： Porazinski S,Ladomery M

更新日期：2018-03-13 00:00:00

abstract：:Breast cancer is one of the most common malignancies in women. Patient-derived tumor xenograft (PDX) model is a cutting-edge approach for drug research on breast cancer. However, PDX still exhibits differences from original human tumors, thereby challenging the molecular understanding of tumorigenesis. In particular, ...

journal_title：Genes

authors： Wang D,Li JR,Zhang YH,Chen L,Huang T,Cai YD

更新日期：2018-03-12 00:00:00

abstract：:Deinococcus species display a high degree of resistance to radiation and desiccation due to their ability to protect critical proteome from oxidatively generated damage; however, the underlying mechanisms are not understood. Comparative analysis of DNA repair proteins reported here has identified 22 conserved signatur...

journal_title：Genes

authors： Hassan FMN,Gupta RS

更新日期：2018-03-08 00:00:00

abstract：:Increasing evidence suggests that dysregulation of microRNAs (miRNAs) may lead to a variety of diseases. Therefore, identifying disease-related miRNAs is a crucial problem. Currently, many computational approaches have been proposed to predict binary miRNA-disease associations. In this study, in order to predict under...

journal_title：Genes

authors： Zhang X,Yin J,Zhang X

更新日期：2018-03-02 00:00:00

abstract：:Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2 new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease, various prevention measures are being studied, one of which are anthocyanin-rich foods. Anthocyanins are potent antioxidant flavonoids m...

journal_title：Genes

authors： Fernández J,García L,Monte J,Villar CJ,Lombó F

更新日期：2018-03-01 00:00:00

abstract：:coalescence methods have emerged as a popular alternative for inferring species trees with large genomic datasets, because these methods explicitly account for incomplete lineage sorting. However, statistical consistency of summary coalescence methods is not guaranteed unless several model assumptions are true, includ...

journal_title：Genes

authors： Springer MS,Gatesy J

更新日期：2018-02-26 00:00:00

abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...

journal_title：Genes

authors： Lima AR,Santos L,Correia M,Soares P,Sobrinho-Simões M,Melo M,Máximo V

更新日期：2018-02-21 00:00:00

abstract：:We analysed nine microsatellite markers for 626 individuals representing the geographic range of eight closely related endemic New Zealand species of Sophora. Structure analysis identified the optimal K value as seven, with samples identified as Sophorachathamica, Sophorafulvida, Sophoralongicarinata, and Sophoraprost...

journal_title：Genes

authors： Heenan P,Mitchell C,Houliston G

更新日期：2018-02-20 00:00:00

abstract：:Wnt is a complex signaling pathway involved in the regulation of crucial biological functions such as development, proliferation, differentiation and migration of cells, mainly stem cells, which are virtually present in all embryonic and adult tissues. Conversely, dysregulation of Wnt signal is implicated in developme...

journal_title：Genes

authors： Zuccarini M,Giuliani P,Ziberi S,Carluccio M,Iorio PD,Caciagli F,Ciccarelli R

更新日期：2018-02-17 00:00:00

abstract：:Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...

journal_title：Genes

authors： Belk A,Xu ZZ,Carter DO,Lynne A,Bucheli S,Knight R,Metcalf JL

更新日期：2018-02-16 00:00:00

abstract：:Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...

journal_title：Genes

authors： Damiati S,Peacock M,Leonhardt S,Damiati L,Baghdadi MA,Becker H,Kodzius R,Schuster B

更新日期：2018-02-14 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens associated with outbreaks and hemolytic-uremic syndrome. Cattle and meat foods are the main reservoir and infection source, respectively. Pathogenicity islands (PAIs) play an important role in STEC pathogenicity, and non-locus of the enterocyte effa...

journal_title：Genes

authors： Soledad-Cadona J,Bustamante AV,González J,Mariel-Sanso A

更新日期：2018-02-10 00:00:00

abstract：:In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but only ADAR2a and AD...

journal_title：Genes

authors： Filippini A,Bonini D,Giacopuzzi E,La Via L,Gangemi F,Colombi M,Barbon A

更新日期：2018-02-08 00:00:00

abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

journal_title：Genes

authors： Dardis A,Buratti E

更新日期：2018-02-06 00:00:00

abstract：:The homeodomain-leucine zipper (HD-Zip) gene family, as plant-specific transcription factors, plays an important role in plant development and growth as well as in the response to diverse stresses. Although HD-Zip genes have been extensively studied in many plants, they had not yet been studied in wheat, especially th...

journal_title：Genes

authors： Yue H,Shu D,Wang M,Xing G,Zhan H,Du X,Song W,Nie X

更新日期：2018-02-01 00:00:00

abstract：:The recently discovered Methanonatronarchaeia are extremely halophilic and moderately thermophilic methyl-reducing methanogens representing a novel class-level lineage in the phylum Euryarchaeota related to the class Halobacteria. Here we present a detailed analysis of 1D-nano liquid chromatography-electrospray ioniza...

journal_title：Genes

authors： Ferrer M,Sorokin DY,Wolf YI,Ciordia S,Mena MC,Bargiela R,Koonin EV,Makarova KS

更新日期：2018-01-23 00:00:00

abstract：:Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is s...

journal_title：Genes

authors： Erzurumluoglu AM,Baird D,Richardson TG,Timpson NJ,Rodriguez S

更新日期：2018-01-22 00:00:00

abstract：:Individual cells in an organism are variable, which strongly impacts cellular processes. Advances in sequencing technologies have enabled single-cell genomic analysis to become widespread, addressing shortcomings of analyses conducted on populations of bulk cells. While the field of single-cell plant genomics is in it...

journal_title：Genes

authors： Yuan Y,Lee H,Hu H,Scheben A,Edwards D

更新日期：2018-01-22 00:00:00

abstract：:Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...

journal_title：Genes

authors： Ravaioli F,Bacalini MG,Franceschi C,Garagnani P

更新日期：2018-01-16 00:00:00

abstract：:Shewanella oneidensis MR-1 can transfer electrons from the intracellular environment to the extracellular space of the cells to reduce the extracellular insoluble electron acceptors (Extracellular Electron Transfer, EET). Benefiting from this EET capability, Shewanella has been widely used in different areas, such as ...

journal_title：Genes

authors： Ding D,Sun X

更新日期：2018-01-16 00:00:00

abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...

journal_title：Genes

authors： Li C,Lin F,An D,Wang W,Huang R

更新日期：2017-12-28 00:00:00

abstract：:In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...

journal_title：Genes

authors： Hadjadj L,Riziki T,Zhu Y,Li J,Diene SM,Rolain JM

更新日期：2017-12-19 00:00:00

abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...

journal_title：Genes

authors： Geng MT,Min Y,Yao Y,Chen X,Fan J,Yuan S,Wang L,Sun C,Zhang F,Shang L,Wang YL,Li RM,Fu SP,Duan RJ,Liu J,Hu XW,Guo JC

更新日期：2017-12-15 00:00:00

abstract：:Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...

journal_title：Genes

authors： Xing L,Zhu M,Zhang M,Li W,Jiang H,Zou J,Wang L,Xu M

更新日期：2017-12-14 00:00:00

abstract：:Despite worldwide prevention programs, the incidence for cutaneous melanoma is continuously increasing. Mucosal melanoma (MM) represents a rare but highly aggressive phenotype of common melanoma with predilection in the sinonasal system. Far away from ultraviolet sun exposure, the molecular mechanisms underlying tumor...

journal_title：Genes

authors： Fritsche MK,Knopf A

更新日期：2017-12-13 00:00:00

abstract：:The northern sea otter inhabits coastal waters of the northern Pacific Ocean and is the largest member of the Mustelidae family. DNA sequencing methods that utilize microfluidic partitioned and non-partitioned library construction were used to establish the sea otter genome. The final assembly provided 2.426 Gbp of hi...

journal_title：Genes

authors： Jones SJ,Haulena M,Taylor GA,Chan S,Bilobram S,Warren RL,Hammond SA,Mungall KL,Choo C,Kirk H,Pandoh P,Ally A,Dhalla N,Tam AKY,Troussard A,Paulino D,Coope RJN,Mungall AJ,Moore R,Zhao Y,Birol I,Ma Y,Marra M,Jo

更新日期：2017-12-11 00:00:00

abstract：:Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...

journal_title：Genes

authors： Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

更新日期：2017-12-05 00:00:00

abstract：:Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...

journal_title：Genes

authors： Powell AF,Doyle JJ

更新日期：2017-11-30 00:00:00

abstract：:The availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to understand the evolutionary dynamics of their tandem repeat sequences (satellites), as a result of ev...

journal_title：Genes

authors： Subirana JA,Messeguer X

更新日期：2017-11-28 00:00:00

abstract：:Unbalanced dietary habits and gut dysmotility are causative factors in metabolic and functional gut disorders, including obesity, diabetes, and constipation. Reduction in luminal butyrate synthesis is known to be associated with gut dysbioses, and studies have suggested that restoring butyrate formation in the colon m...

journal_title：Genes

authors： Hwang N,Eom T,Gupta SK,Jeong SY,Jeong DY,Kim YS,Lee JH,Sadowsky MJ,Unno T

更新日期：2017-11-28 00:00:00

abstract：:White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible in...

journal_title：Genes

authors： Yi S,Li Y,Shi L,Zhang L

更新日期：2017-11-10 00:00:00

abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is involved in DNA repair pathways as it mends the topoisomerase I-DNA covalent complexes. In plants, a small Tdp1 gene family, composed by Tdp1α and Tdp1β genes, was identified, but the roles of these genes in abiotic stress responses are not fully understood. To investigate the...

journal_title：Genes

authors： Sabatini ME,Pagano A,Araùjo S,Balestrazzi A,Macovei A

更新日期：2017-11-03 00:00:00